Manuscript on pulmonary hypertension due to schistosomiasis versus portal hypertension published

In collaboration with several colleagues in Brazil and elsewhere, we published an opinion piece in JHLT Open distinguishing pulmonary arterial hypertension due to schistosomiasis from that due to portal hypertension.  https://www.jhltopen.org/article/S2950-1334(23)00007-1/fulltext

R21 Grant Received

In collaboration with Dr. Joan Hilton (the contact PI: UCSF Dept of Epidemiology and Biostatistics), we received an R21 grant to study diagnostic prediction models in PAH, with screening for schistosomiasis-PAH in at-risk populations in Ethiopia and Zambia.

ATS 2023 Presentations by our Group

Our group is presenting several abstracts on our active research projects at the 2023 American Thoracic Society International Conference in Washington DC: Role of T Lymphocyte Location in Schistosoma-induced Pulmonary Hypertension. First author: Dara Fonseca Balladares (UCSF) Role of Inflammatory...

Repetitive Schistosoma exposure paper published

We published that repeated Schistosoma egg exposure induces persistent vascular remodeling associated with perivascular fibrosis. This was a great collaboration with researchers at the University of Colorado and Stanford.   https://pubmed.ncbi.nlm.nih.gov/37014925/

UCSF RAP Grant Received

In collaboration with Joan Hilton, ScD, MPH in the Department of Epidemiology and Biostatistics (https://profiles.ucsf.edu/joan.hilton), we received a UCSF Research Allocation Program (RAP) Team Science Grant.

Schistosomiasis-pulmonary hypertension review published

A review written by Brian Graham on schistosomiasis associated pulmonary arterial hypertension was published in Advances in Pulmonary Hypertension. https://meridian.allenpress.com/aph/article/21/4/109/489433/Schistosomiasis-Associated-Pulmonary-Arterial

Review paper on exercise metabolomics published

Dr. Michael Lee is the first author on a review paper published in Frontiers in Physiology, which covers exercise physiology in pulmonary hypertension and its relationship to metabolism of the pulmonary vasculature. The senior author is close collaborator Dr. Rudolf Oliveira at the Federal...

Paper describing RV macrophage role published

Collaborator Dr. Sue Gu at UCDenver was the first author of a publication in Pulmonary Circulation on the role of right ventricle macrophages in pulmonary hypertension. We found an increase in a population of interstitital RV macrophages, and clodronate treatment to deplete monocytes/macrophages...

Paper describing fatty acid oxidation in pulmonary hypertension published

Congratulations Dr. Michael Lee for publishing in AJP-Lung on the role of fatty acid oxidation in pulmonary hypertension, using a combination of human tissue analysis and animal model work.  https://pubmed.ncbi.nlm.nih.gov/35763400/

Paper describing the use of dexamethasone as prophylaxis for high altitude disease published

This clinical study led by Prof. Pasha (IGIB, India) found that dexamethasone prophylaxis prior to travelling to high elevation benefits women more than men, including preventing the acute rise in right ventricle systolic pressure. Drs. Rahul Kumar and Brian Graham were co-authors on this paper,...