Rahul Kumar, PhD

Assistant Adjunct Professor
ZSFG Pulmonary
[email protected]
Publications: 

Experimental Schistosoma haematobium pulmonary hypertension.

Pulmonary circulation

Kassa B, Fonseca-Balladares DC, Kumar R, Lee MH, Mickael C, Sanders L, Nolan K, Graham BB

Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome.

Bioscience reports

Kumar R, Chanana N, Sharma K, Palmo T, Lee MH, Mishra A, Nolan K, Fonseca Balladares DC, Mickael C, Gupta MD, Thinlas T, Pasha Q, Graham BB

Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?

JHLT open

Graham BB, Hilton JF, Lee MH, Kumar R, Balladares DF, Rahaghi FN, Estépar RSJ, Mickael C, Lima RLB, Loureiro CMC, Lucena J, Oliveira RKF, Corrêa RA

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.

Clinical science (London, England : 1979)

Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: Multilayered cross-talks in the setting of coinfections and comorbidities.

PLoS pathogens

Kumar R, Aktay-Cetin ?, Craddock V, Morales-Cano D, Kosanovic D, Cogolludo A, Perez-Vizcaino F, Avdeev S, Kumar A, Ram AK, Agarwal S, Chakraborty A, Savai R, de Jesus Perez V, Graham BB, Butrous G, Dhillon NK

HIV and Schistosoma Co-Exposure Leads to Exacerbated Pulmonary Endothelial Remodeling and Dysfunction Associated with Altered Cytokine Landscape.

Cells

Medrano-Garcia S, Morales-Cano D, Barreira B, Vera-Zambrano A, Kumar R, Kosanovic D, Schermuly RT, Graham BB, Perez-Vizcaino F, Mathie A, Savai R, Pullamseti S, Butrous G, Fernández-Malavé E, Cogolludo A

The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension.

Pulmonary circulation

Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB

Contribution of Fatty Acid Oxidation to the Pathogenesis of Pulmonary Hypertension.

American journal of physiology. Lung cellular and molecular physiology

Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM

Single Cell RNA Sequencing and Binary Hierarchical Clustering Defines Lung Interstitial Macrophage Heterogeneity in Response to Hypoxia.

American journal of physiology. Lung cellular and molecular physiology

Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR

Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure.

Frontiers in pharmacology

Chanana N, Palmo T, Sharma K, Kumar R, Shah B, Mahajan S, Palleda GM, Gupta MD, Kukreti R, Faruq M, Thinlas T, Graham BB, Pasha Q

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY

Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.

Pulmonary circulation

Sinkala E, Ahmed HY, Sibomana JP, Lee MH, Kassa B, Kumar R, Mazimba S, Binegdie AB, Mpisa S, Wamundila K, Graham BB, Hilton JF

Experimental Schistosoma japonicum-induced pulmonary hypertension.

PLoS neglected tropical diseases

Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB

Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB

Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension.

Cellular & molecular immunology

Florentin J, Zhao J, Tai YY, Vasamsetti SB, O'Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P

Schistosomiasis Pulmonary Arterial Hypertension.

Frontiers in immunology

Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, Silva LCS, Sinkala E, Ahmed HY, Graham BB

Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.

ERJ open research

Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B

Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.

Cardiovascular research

Kumar R, Mickael C, Kassa B, Sanders L, Hernandez-Saavedra D, Koyanagi DE, Kumar S, Pugliese SC, Thomas S, McClendon J, Maloney JP, Janssen WJ, Stenmark KR, Tuder RM, Graham BB

Sex-derived attributes contributing to SARS-CoV-2 mortality.

American journal of physiology. Endocrinology and metabolism

Chanana N, Palmo T, Sharma K, Kumar R, Graham BB, Pasha Q

Susceptibility to high-altitude pulmonary edema is associated with circulating miRNA levels under hypobaric hypoxia conditions.

American journal of physiology. Lung cellular and molecular physiology

Alam P, Agarwal G, Kumar R, Mishra A, Saini N, Mohammad G, Pasha MAQ

Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

Scientific reports

Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

Scientific reports

Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB

Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension.

Journal of the American Heart Association

Kumar R, Mickael C, Kassa B, Sanders L, Koyanagi D, Hernandez-Saavedra D, Freeman S, Morales-Cano D, Cogolludo A, McKee AS, Fontenot AP, Butrous G, Tuder RM, Graham BB

IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.

American journal of respiratory cell and molecular biology

Mickael C, Kumar R, Hernandez-Saavedra D, Kassa B, Sanders L, Koyanagi D, Gu S, Lee MH, Tuder RM, Graham BB

BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.

Circulation

Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY

Common genetic variants in pulmonary arterial hypertension.

The Lancet. Respiratory medicine

Gu S, Kumar R, Lee MH, Mickael C, Graham BB

Paclitaxel blocks Th2-mediated TGF-β activation in Schistosoma mansoni-induced pulmonary hypertension.

Pulmonary circulation

Kassa B, Mickael C, Kumar R, Sanders L, Koyanagi D, Hernandez-Saavedra D, Tuder RM, Graham BB

Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.

American journal of respiratory cell and molecular biology

Graham BB, Kumar R, Mickael C, Kassa B, Koyanagi D, Sanders L, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Harral J, Loomis Z, Irwin D, Nemkov T, D'Alessandro A, Stenmark KR, Tuder RM

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Science translational medicine

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA

How does inflammation contribute to pulmonary hypertension?

The European respiratory journal

Kumar R, Graham B

TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.

Nature communications

Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB

Impact of interactions between risk alleles on clinical endpoints in hypertension.

Heart Asia

Kohli S, Kumar R, Gupta M, Tyagi S, Pasha MA

Unveiling the interactions among BMPR-2, ALK-1 and 5-HTT genes in the pathophysiology of HAPE.

Gene

Ali Z, Waseem M, Kumar R, Pandey P, Mohammad G, Qadar Pasha MA

Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit.

Cell reports

Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY

The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.

American journal of respiratory and critical care medicine

Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.

American journal of physiology. Lung cellular and molecular physiology

Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez M, Smith-Jones P, Serkova NJ, Tuder RM

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.

EMBO molecular medicine

White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY

CYBA (p22phox) variants associate with blood pressure and oxidative stress markers in hypertension: a replication study in populations of diverse altitudes.

Hypertension research : official journal of the Japanese Society of Hypertension

Kumar R, Kohli S, Ali Z, Duhan K, Ram R, Gupta M, Tyagi S, Mohammad G, Pasha MQ

Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension.

American journal of hypertension

Kumar R, Kohli S, Mishra A, Garg R, Alam P, Stobdan T, Nejatizadeh A, Gupta M, Tyagi S, Pasha MA

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

The Journal of clinical investigation

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY

ß-T594M epithelial sodium channel gene polymorphism and essential hypertension in individuals of Indo-Aryan ancestry in Northern India.

Indian heart journal

Gupta MD, Girish MP, Sikdar S, Ahuja R, Shah D, Kumar R, Rain M, Nejatizadeh A, Tyagi S, Pasha Q

Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.

Pulmonary circulation

Chabon JJ, Gebreab L, Kumar R, Debella E, Tanaka T, Koyanagi D, Rodriguez Garcia A, Sanders L, Perez M, Tuder RM, Graham BB

Association between the Glu298Asp and 4b/4a polymorphisms of endothelial nitric oxide synthase and coronary slow flow in the North Indian population.

Coronary artery disease

Gupta MD, Akkarappatty C, Girish MP, Kumar R, Rain M, Tyagi S, Qadar Pasha MA

Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.

American journal of respiratory cell and molecular biology

Graham BB, Chabon J, Kumar R, Kolosionek E, Gebreab L, Debella E, Edwards M, Diener K, Shade T, Bifeng G, Bandeira A, Butrous G, Jones K, Geraci M, Tuder RM

Pathology of pulmonary hypertension.

Clinics in chest medicine

Tuder RM, Stacher E, Robinson J, Kumar R, Graham BB

Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension.

PloS one

Kumar R, Kohli S, Alam P, Barkotoky R, Gupta M, Tyagi S, Jain SK, Pasha MA

Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders.

PloS one

Ali Z, Mishra A, Kumar R, Alam P, Pandey P, Ram R, Thinlas T, Mohammad G, Pasha MA

CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema.

Clinical science (London, England : 1979)

Mishra A, Ali Z, Vibhuti A, Kumar R, Alam P, Ram R, Thinlas T, Mohammad G, Pasha MA

The epistasis between vascular homeostasis genes is apparent in essential hypertension.

Atherosclerosis

Kumar R, Nejatizadeh A, Gupta M, Markan A, Tyagi S, Jain SK, Pasha MA

Association of GNB3 C825T polymorphism with plasma electrolyte balance and susceptibility to hypertension.

Genetics and molecular biology

Nejatizadeh A, Kumar R, Stobdan T, Pasha MQ

CYP11B2 gene haplotypes independently and in concurrence with aldosterone and aldosterone to renin ratio increase the risk of hypertension.

Clinical biochemistry

Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Tyagi S, Jain SK, Pasha MA

Multi-locus interactions of vascular homeostasis genes in essential hypertension: a gender-based study.

Clinica chimica acta; international journal of clinical chemistry

Kumar R, Nejatizadeh A, Arif E, Akhtar S, Gupta M, Tyagi S, Goyal AK, Jain SK, Qadar Pasha MA

Significance of angiotensinogen gene haplotypes and genotypes combinations in hypertension.

Journal of hypertension

Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Gupta M, Javed S, Pasha MQ

Endothelial nitric oxide synthase gene haplotypes and circulating nitric oxide levels significantly associate with risk of essential hypertension.

Free radical biology & medicine

Nejatizadeh A, Kumar R, Stobdan T, Goyal AK, Sikdar S, Gupta M, Javed S, Pasha MA