Michael Lee, MD

Breathing New Life into PAH Treatment: Targeting Serotonin Synthesis with an Inhalation Approach.

American journal of respiratory cell and molecular biology

Lee MH, Kumar R

Physiologic relevance of the transpulmonary metabolome in connective tissue disease-associated pulmonary vascular disease.

JCI insight

Lee MH, Menezes TCF, Reisz JA, Cendali FI, Ferreira EVM, Ota-Arakaki JS, Sperandio PA, Kumar R, Mickael C, Ieong MM, Santos JL, Duarte ACB, Fonseca Balladares DC, Nolan K, Tuder RM, Hassoun PM, D'Alessandro A, Oliveira RKF, Graham BB

Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance.

Journal of the American Heart Association

Menezes TCF, Lee MH, Fonseca Balladares DC, Nolan K, Sharma S, Kumar R, Ferreira EVM, Graham BB, Oliveira RKF

Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.

The Journal of clinical investigation

Kumar R, Nolan K, Kassa B, Chanana N, Palmo T, Sharma K, Singh K, Mickael C, Fonseca Balladares D, Nilsson J, Prabhakar A, Mishra A, Lee MH, Sanders L, Kumar S, Molofsky AB, Stenmark KR, Sheppard D, Tuder RM, Gupta MD, Thinlas T, Pasha Q, Graham BB

Pulse Fiction: The SpO2-SaO2 Gap in Methemoglobinemia.

Annals of the American Thoracic Society

Boctor D, Garudadri S, Donzelli G, Lee MH

Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mickael C, Sanders LA, Lee MH, Kumar R, Fonseca-Balladares D, Gandjeva A, Cautivo-Reyes K, Kassa B, Kumar S, Irwin D, Swindle D, Phang T, Stearman RS, Molofsky AB, McKee AS, Stenmark KR, Graham BB, Tuder RM

Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.

International journal of molecular sciences

Fonseca Balladares DC, Kassa B, Mickael C, Kumar R, Nolan K, Menezes TCF, Lee MH, Lau-Xiao AM, Molofsky AB, Wells E, Graham BB

Dyspnea Investigation in Behçet's Disease: The Role of Advanced Diagnostic Methods to Elucidate Dyspnea in Systemic Diseases.

Annals of the American Thoracic Society

Menezes TFC, Lee MH, Lucena J, Sperandio PCA, Ota-Arakaki JS, Ferreira EVM, Oliveira RKF

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.

Frontiers in immunology

Kumar R, Kumar S, Mickael C, Fonseca Balladares D, Nolan K, Lee MH, Sanders L, Nilsson J, Molofsky AB, Tuder RM, Stenmark KR, Graham BB

Pathogenesis of Pulmonary Arterial Hypertension. In: Allanore, Y., Varga, J., Denton, C.P., Kuwana, M., Chung, L., Shah, A.A. (eds) Scleroderma

Pathogenesis of Pulmonary Arterial Hypertension. In: Allanore, Y., Varga, J., Denton, C.P., Kuwana, M., Chung, L., Shah, A.A. (eds) Scleroderma.

Ponticos M, Lee MH, Holmes AM, Tuder RM.

Experimental Schistosoma haematobium pulmonary hypertension.

Pulmonary circulation

Kassa B, Fonseca-Balladares DC, Kumar R, Lee MH, Mickael C, Sanders L, Nolan K, Graham BB

Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome.

Bioscience reports

Kumar R, Chanana N, Sharma K, Palmo T, Lee MH, Mishra A, Nolan K, Fonseca Balladares DC, Mickael C, Gupta MD, Thinlas T, Pasha Q, Graham BB

Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?

JHLT open

Graham BB, Hilton JF, Lee MH, Kumar R, Balladares DF, Rahaghi FN, Estépar RSJ, Mickael C, Lima RLB, Loureiro CMC, Lucena J, Oliveira RKF, Corrêa RA

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.

Clinical science (London, England : 1979)

Kumar R, Lee MH, Kassa B, Fonseca Balladares DC, Mickael C, Sanders L, Andruska A, Kumar M, Spiekerkoetter E, Bandeira A, Stenmark KR, Tuder RM, Graham BB

The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned.

The European respiratory journal

Mickael C, Lee MH, Graham BB

Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology.

Frontiers in physiology

Lee MH, Menezes TCF, Reisz JA, Ferreira EVM, Graham BB, Oliveira RKF

The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension.

Pulmonary circulation

Gu S, Mickael C, Kumar R, Lee MH, Sanders L, Kassa B, Harral J, Williams J, Hansen KC, Stenmark KR, Tuder RM, Graham BB

Contribution of Fatty Acid Oxidation to the Pathogenesis of Pulmonary Hypertension.

American journal of physiology. Lung cellular and molecular physiology

Lee MH, Sanders L, Kumar R, Hernandez-Saavedra D, Yun X, Ford JA, Perez MJ, Mickael C, Gandjeva A, Koyanagi DE, Harral JW, Irwin DC, Kassa B, Eckel RH, Shimoda LA, Graham BB, Tuder RM

Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform.

American journal of respiratory cell and molecular biology

Mickael C, Kheyfets VO, Langouët-Astrié C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM

Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.

Pulmonary circulation

Sinkala E, Ahmed HY, Sibomana JP, Lee MH, Kassa B, Kumar R, Mazimba S, Binegdie AB, Mpisa S, Wamundila K, Graham BB, Hilton JF

Experimental Schistosoma japonicum-induced pulmonary hypertension.

PLoS neglected tropical diseases

Kassa B, Lee MH, Kumar R, Mickael C, Sanders L, Tuder RM, Mentink-Kane M, Graham BB

Double Trouble: Airflow and Pulmonary Vascular Obstruction.

American journal of respiratory and critical care medicine

Lee MH, Graham BB, Bull TM

Pathology of Pulmonary Arterial Hypertension. In: Janes SM, ed. Encyclopedia of Respiratory Medicine

Lee MH, Tuder RM.

Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling.

American journal of respiratory cell and molecular biology

Lee MH, Mickael C, Graham BB

Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.

American journal of physiology. Lung cellular and molecular physiology

Kassa B, Kumar R, Mickael C, Sanders L, Vohwinkel C, Lee MH, Gu S, Poth JM, Stenmark KR, Zhao YY, Tuder RM, Graham BB

Pulmonary Arterial Hypertension and Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Novel Association?

Chest

Lee MH, Doran J, Bang TJ, Hohsfield R, Hountras P, Boddie G, Wagh MS, Badesch D, Bull TM

A Case and Brief Review of Bilious Ascites and Abdominal Compartment Syndrome from Pancreatitis-Induced Post-Roux-En-Y Gastric Remnant Leak

Southwest J Pulm Crit Care.

Martin MA, Lee MH, Neumeier A, Huie TJ.

Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension.

The European respiratory journal

Rahaghi FN, Hilton JF, Corrêa RA, Loureiro C, Ota-Arakaki JS, Verrastro CGY, Lee MH, Mickael C, Nardelli P, Systrom DA, Waxman AB, Washko GR, San José Estépar R, Graham BB, Oliveira RKF

Histopathological Correlation of Acute on Chronic Eosinophilic Pneumonitis Caused by Vaporized Cannabis Oil Inhalation.

Chest

Lee MH, Cool CD, Maloney JP

Schistosomiasis Pulmonary Arterial Hypertension.

Frontiers in immunology

Sibomana JP, Campeche A, Carvalho-Filho RJ, Correa RA, Duani H, Pacheco Guimaraes V, Hilton JF, Kassa B, Kumar R, Lee MH, Loureiro CMC, Mazimba S, Mickael C, Oliveira RKF, Ota-Arakaki JS, Rezende CF, Silva LCS, Sinkala E, Ahmed HY, Graham BB

Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.

ERJ open research

Kumar R, Lee MH, Mickael C, Kassa B, Pasha Q, Tuder R, Graham B

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

Scientific reports

Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D' Alessandro A, Stenmark KR, Tuder RM, Graham BB

Publications

Breathing New Life into PAH Treatment: Targeting Serotonin Synthesis with an Inhalation Approach.

Physiologic relevance of the transpulmonary metabolome in connective tissue disease-associated pulmonary vascular disease.

Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance.

Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.

Pulse Fiction: The SpO2-SaO2 Gap in Methemoglobinemia.

Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.

Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.

Dyspnea Investigation in Behçet's Disease: The Role of Advanced Diagnostic Methods to Elucidate Dyspnea in Systemic Diseases.

Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.

Pathogenesis of Pulmonary Arterial Hypertension. In: Allanore, Y., Varga, J., Denton, C.P., Kuwana, M., Chung, L., Shah, A.A. (eds) Scleroderma

Experimental Schistosoma haematobium pulmonary hypertension.

Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome.

Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?

Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.

The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned.

Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology.

The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension.

Contribution of Fatty Acid Oxidation to the Pathogenesis of Pulmonary Hypertension.

Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform.

Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.

Experimental Schistosoma japonicum-induced pulmonary hypertension.

Double Trouble: Airflow and Pulmonary Vascular Obstruction.

Pathology of Pulmonary Arterial Hypertension. In: Janes SM, ed. Encyclopedia of Respiratory Medicine

Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling.

Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.

Pulmonary Arterial Hypertension and Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Novel Association?

A Case and Brief Review of Bilious Ascites and Abdominal Compartment Syndrome from Pancreatitis-Induced Post-Roux-En-Y Gastric Remnant Leak

Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension.

Histopathological Correlation of Acute on Chronic Eosinophilic Pneumonitis Caused by Vaporized Cannabis Oil Inhalation.

Schistosomiasis Pulmonary Arterial Hypertension.

Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.

Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.

The role of pulmonary arterial hypertension-targeted therapy in systemic sclerosis.

IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.

Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective.

Common genetic variants in pulmonary arterial hypertension.

Cystine growth inhibition through molecular mimicry: a new paradigm for the prevention of crystal diseases.

Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular design.