
Professor In Residence
ZSFG Pulmonary
+1 628 206-4422
I am the Division Chief of Pulmonary and Critical Care Medicine at Zuckerberg San Francisco General Hospital, and a Professor in Residence at UCSF. My primary clinical and research interest is in pulmonary hypertension. I particularly study schistosomiasis associated pulmonary hypertension, a common cause worldwide.
Publications
Morbidity and Mortality Associated With Pulmonary Arterial Hypertension in a Schistosomiasis-Endemic Region of Brazil.
Pulmonary circulation
High Altitude May Protect Against the Early Development of Irreversible Pulmonary Hypertension in Patients With Congenital Heart Disease.
Pulmonary circulation
Clinical, Functional, and Hemodynamic Profile of Schistosomiasis-Associated Pulmonary Arterial Hypertension Patients in Brazil: Systematic Review and Meta-Analysis.
Infectious disease reports
Skeletal Muscle Pathology in Pulmonary Arterial Hypertension and Its Contribution to Exercise Intolerance.
Journal of the American Heart Association
Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension.
The Journal of clinical investigation
Reply to the letter to the editor entitled "Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms" by Perros F. et al.
Pulmonary circulation
Activation of Platelets and the Complement System in Mice with Schistosoma-Induced Pulmonary Hypertension.
American journal of physiology. Lung cellular and molecular physiology
Classical dendritic cells contribute to hypoxia-induced pulmonary hypertension.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Intrapulmonary T Cells Are Sufficient for Schistosoma-Induced Pulmonary Hypertension.
International journal of molecular sciences
Two hits strike out causing persistent pulmonary hypertension in mice.
American journal of physiology. Lung cellular and molecular physiology
Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
Nature cardiovascular research
Interstitial macrophage phenotypes in Schistosoma-induced pulmonary hypertension.
Frontiers in immunology
Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension.
Frontiers in immunology
Hypobaric hypoxia modulated structural characteristics of circulating cell free DNA in high altitude pulmonary edema.
American journal of physiology. Lung cellular and molecular physiology
Experimental Schistosoma haematobium pulmonary hypertension.
Pulmonary circulation
Hypobaric hypoxia drives selection of altitude-associated adaptative alleles in the Himalayan population.
The Science of the total environment
Dexamethasone prophylaxis protects from acute high-altitude illness by modifying the peripheral blood mononuclear cell inflammatory transcriptome.
Bioscience reports
Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
bioRxiv : the preprint server for biology
PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells.
American journal of respiratory cell and molecular biology
Repetitive schistosoma exposure causes perivascular lung fibrosis and persistent pulmonary hypertension.
Clinical science (London, England : 1979)
Functional and Molecular Determinants of Right Ventricular Response to Severe Pulmonary Hypertension in a Large Animal Model.
American journal of physiology. Heart and circulatory physiology
The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned.
The European respiratory journal
Exercise metabolomics in pulmonary arterial hypertension: Where pulmonary vascular metabolism meets exercise physiology.
Frontiers in physiology
The role of macrophages in right ventricular remodeling in experimental pulmonary hypertension.
Pulmonary circulation
Contribution of Fatty Acid Oxidation to the Pathogenesis of Pulmonary Hypertension.
American journal of physiology. Lung cellular and molecular physiology
Single Cell RNA Sequencing and Binary Hierarchical Clustering Defines Lung Interstitial Macrophage Heterogeneity in Response to Hypoxia.
American journal of physiology. Lung cellular and molecular physiology
Sexual Dimorphism of Dexamethasone as a Prophylactic Treatment in Pathologies Associated With Acute Hypobaric Hypoxia Exposure.
Frontiers in pharmacology
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
The Journal of clinical investigation
Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform.
American journal of respiratory cell and molecular biology
Rationale and design of a screening study to detect schistosomiasis-associated pulmonary hypertension in Ethiopia and Zambia.
Pulmonary circulation
Experimental Schistosoma japonicum-induced pulmonary hypertension.
PLoS neglected tropical diseases
Double Trouble: Airflow and Pulmonary Vascular Obstruction.
American journal of respiratory and critical care medicine
Two Birds with One Stone: Helping the Pulmonary Arteries and the Right Ventricle by Targeting BMPR2 Signaling.
American journal of respiratory cell and molecular biology
Endothelial cell PHD2-HIF1α-PFKFB3 contributes to right ventricle vascular adaptation in pulmonary hypertension.
American journal of physiology. Lung cellular and molecular physiology
Arterial vascular volume changes with haemodynamics in schistosomiasis-associated pulmonary arterial hypertension.
The European respiratory journal
Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension.
Cellular & molecular immunology
Schistosomiasis Pulmonary Arterial Hypertension.
Frontiers in immunology
Pathophysiology and potential future therapeutic targets using preclinical models of COVID-19.
ERJ open research
Interstitial macrophage-derived thrombospondin-1 contributes to hypoxia-induced pulmonary hypertension.
Cardiovascular research
Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine.
American journal of respiratory cell and molecular biology
Sex-derived attributes contributing to SARS-CoV-2 mortality.
American journal of physiology. Endocrinology and metabolism
Publisher Correction: Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.
Scientific reports
Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment.
Scientific reports
Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.
The European respiratory journal
Th2 CD4+ T Cells Are Necessary and Sufficient for Schistosoma-Pulmonary Hypertension.
Journal of the American Heart Association
A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil.
International journal of cardiology. Heart & vasculature
IL-6Ra in Smooth Muscle Cells Protects against Schistosoma- and Hypoxia-induced Pulmonary Hypertension.
American journal of respiratory cell and molecular biology
Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome.
American journal of respiratory cell and molecular biology
Comparing pulmonary hypertension severity between rat strains suggests right ventricle NK cells are protective.
Cardiovascular research
The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension.
Frontiers in immunology
Finding the Target: In Silico and Genetic Screening for Mechanistically Novel Drugs in Pulmonary Arterial Hypertension.
American journal of respiratory and critical care medicine
Common genetic variants in pulmonary arterial hypertension.
The Lancet. Respiratory medicine
Paclitaxel blocks Th2-mediated TGF-β activation in Schistosoma mansoni-induced pulmonary hypertension.
Pulmonary circulation
Vascular Adaptation of the Right Ventricle in Experimental Pulmonary Hypertension.
American journal of respiratory cell and molecular biology
Urocortin 2: will a drug targeting both the vasculature and the right ventricle be the future of pulmonary hypertension therapy?
Cardiovascular research
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Science translational medicine
Dominant Role for Regulatory T Cells in Protecting Females Against Pulmonary Hypertension.
Circulation research
Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension.
Cardiovascular research
Right Ventricle Vasculature in Human Pulmonary Hypertension Assessed by Stereology.
American journal of respiratory and critical care medicine
TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.
Nature communications
A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension.
Journal of immunology (Baltimore, Md. : 1950)
Enhanced inflammatory cell profiles in schistosomiasis-induced pulmonary vascular remodeling.
Pulmonary circulation
Fatty Acid Metabolism, Bone Morphogenetic Protein Receptor Type 2, and the Right Ventricle.
American journal of respiratory and critical care medicine
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
The Journal of clinical investigation
The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.
American journal of respiratory and critical care medicine
Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.
American journal of physiology. Lung cellular and molecular physiology
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
EMBO molecular medicine
The crossroads of iron with hypoxia and cellular metabolism. Implications in the pathobiology of pulmonary hypertension.
American journal of respiratory cell and molecular biology
Schistosomiasis and the pulmonary vasculature (2013 Grover Conference series).
Pulmonary circulation
Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation.
The American journal of pathology
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
The Journal of clinical investigation
Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension.
Journal of immunology (Baltimore, Md. : 1950)
Role of vascular endothelial growth factor signaling in Schistosoma-induced experimental pulmonary hypertension.
Pulmonary circulation
Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.
American journal of respiratory and critical care medicine
Fat and cardiotoxicity in hereditary pulmonary hypertension.
American journal of respiratory and critical care medicine
Protective role of IL-6 in vascular remodeling in Schistosoma pulmonary hypertension.
American journal of respiratory cell and molecular biology
Updated approach for the assessment of ventilator-associated pneumonia.
Critical care medicine
Pathology of pulmonary hypertension.
Clinics in chest medicine
Pulmonary veins in the normal lung and pulmonary hypertension due to left heart disease.
American journal of physiology. Lung cellular and molecular physiology
Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni.
Circulation
A sinus venosus atrial septal defect is diagnosed by echocardiography with an unusual bubble study.
Echocardiography (Mount Kisco, N.Y.)
Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study.
Pulmonary circulation
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.
Cell metabolism
Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year.
Annals of the American Thoracic Society
Modern age pathology of pulmonary arterial hypertension.
American journal of respiratory and critical care medicine
Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension.
American journal of respiratory and critical care medicine
Significant intrapulmonary Schistosoma egg antigens are not present in schistosomiasis-associated pulmonary hypertension.
Pulmonary circulation
Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.
The American journal of pathology
Tracheal Basal cells: a facultative progenitor cell pool.
The American journal of pathology
Diabetes mellitus does not adversely affect outcomes from a critical illness.
Critical care medicine
[Pathogenesis of pulmonary hypertension].
Zhonghua yi xue za zhi
TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.
American journal of physiology. Lung cellular and molecular physiology
Clinical problem-solving. Kiss of death.
The New England journal of medicine
Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung.
American journal of respiratory cell and molecular biology
Primary pulmonary lymphoma.
The Annals of thoracic surgery
End-to-side venous anastomosis with the internal jugular vein stump: a preliminary report.
Head & neck
Pediatric tracheal surgery.
The Annals of thoracic surgery